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PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells

✍ Scribed by Ghosh, Mrinal K; Sharma, Pankaj; Harbor, Phyllis C; Rahaman, Shaik O; Haque, S Jaharul

Book ID: 110069936
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 456 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208894

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## Abstract We recently demonstrated the activation of phosphatidylinositol 3‐kinase (PI3‐K/Akt) survival pathway in Jurkat T leukemia cells known for their sensitivity to the tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL)/Apo2L cytotoxic action. The present investigation was