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PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation

✍ Scribed by C. Marcela Díaz-Montero; James N. Wygant; Bradley W. McIntyre

Book ID
118435704
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
516 KB
Volume
42
Category
Article
ISSN
0959-8049

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✍ Marie-Josée Demers; Sonya Thibodeau; Dominique Noël; Naoya Fujita; Takashi Tsuru 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 527 KB

## Abstract Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs). We report that: (1) cancer cells display striking anoi