W1967 Colon Cancer Cells and Anoikis Resistance: EGFR-Dependent Sustained Activation of the SRC-MEK/ERK Pathway Can Override Dependance On FAK, PI3-K/AKT-1 for Survival

Intestinal epithelial cancer cell anoiki

Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1

✍ Marie-Josée Demers; Sonya Thibodeau; Dominique Noël; Naoya Fujita; Takashi Tsuru 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 527 KB

## Abstract Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs). We report that: (1) cancer cells display striking anoi