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PI LBEI and PI JHOU: two new alpha-1-antitrypsin alleles

✍ Scribed by Qi-long Ying; Chih-chuan Liang; Mei-lin Zhang

Publisher
Springer
Year
1984
Tongue
English
Weight
541 KB
Volume
68
Category
Article
ISSN
0340-6717

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✦ Synopsis

Two new variants of alpha-1-antitrypsin were found in a Chinese population by isoelectric focusing in polyacrylamide gel. They have been named Lbeijing (PI*LBEI) and Jhouyao (PI*JHOU) respectively. With the samples reduced and alkylated, both the variants were anodal to M1 and cathodal to L. Omitting the alkylation step, however, the relative mobilities of L and Jhouyao were altered. Under this condition, a characteristic of Jhouyao was revealed by isoelectric focusing in immobilized pH gradient 4.4-4.9, i.e., while its band 6 became anodal to L, band 4 was still cathodal to L.

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