Rare alpha 1 antitrypsin allele PI W and a history of infant liver disease

Molecular pathogenesis of alpha-1-antitr

Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: A meeting review

✍ David H. Perlmutter; Jeffrey L. Brodsky; William F. Balistreri; Bruce C. Trapnel 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB

In recent years, we have witnessed several important paradigm shifts in understanding the molecular basis of liver disease in alpha-1-antitrypsin (AT) deficiency. These shifts have become possible as a result of a number of advances in research on the cell biology of aggregation-prone mutant protein