Phytoquinoids and Secoprezizaane-Type Sesquiterpenes from Illicium arborescens

✍ Scribed by Jiun-Yang Chang; Mohamed H. Abd El-Razek; Yu-Hui Chen; Yuan-Bin Cheng; Shun-Ying Chen; Ching-Te Chien; Yao-Haur Kuo; Ya-Ching Shen

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 241 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900133

✦ Synopsis

Abstract

A phytochemical investigation of the MeOH extract of Illicium arborescens yielded the two new phytoquinoid epimers, 2,3‐didehydro‐5‐O‐methyl‐11‐epiillifunone E (1) and 2,3‐didehydro‐5‐O‐methylillifunone E (2), as well as five new sesquiterpene lactones (8,9‐secoprezizaane‐type sesquiterpenes). Two of them, i.e., 3 and 4, were minwanensin‐type sesquiterpenes, the other two, i.e., 5 and 6, had the anisatin‐type (or floridanolide type) skeleton, and the fifth, i.e., 7, was a dunnianin‐type sesquiterpene. Their structures were established by analyses of 1D‐ and 2D‐NMR, HR‐MS, and chemical evidence. The in vitro cytotoxic activity of compounds 1–7 was tested against four human tumor cell lines, including HeLa (cervical epitheloid), WiDr (colon), Daoy (medulloblastoma), and Hep2 (liver carcinoma) human‐tumor cells.