✦ LIBER ✦

Physiologie und Biochemie der Streptomyceten XIII. Biosynthese von Paromomycin unter Einsatz von 14C-Glucose, -Glucosamin, -2-Desoxystreptamin und -Ribose durch Streptomyces albus var. metamycinus nov. var.

✍ Scribed by Prof. Dr. G. Reuter; H. Köster; B. Liebermann

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 295 KB
Volume: 17
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19770170707

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✦ Synopsis

Abstract

Distribution of radioactivity in paromomycin ascertained after application of ^14^C‐D‐glucose, ^14^C‐D‐glucosamine, ^14^C‐2‐deoxystreptamine, respectively, ^14^C‐D‐ribose is taken as basis for a biosynthesis scheme: While ribose bound in the antibiotic originates from glucose by oxidation and following decarboxylation, glucosamine is formed via fructose‐6‐phosphate. Paromose I arises from glucosamine, but not the cyclohexan derivative 2‐deoxystreptamine, whose biosynthesis pathway is directly branching off glucose.

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Physiologie und Biochemie der Streptomyceten. III. Einbau von D-Glucose-u-14C in Paromomycin als Indikator für die Antibioticabildung durch Streptomyces albus var. metamycinus nov. var.

✍ H. Köster; B. Liebermann; Prof. Dr. G. Reuter 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 527 KB

## Abstract Paromomycin was isolated from culture filtrates of __Streptomyces albus var. metamycinus nov. var.__ after feeding the growing cultures with D‐glucose‐u‐^14^C. From the different incorporation rates conclusions concerning different features of the paromomycin biosynthesis (utilization o