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Physiologie und Biochemie der Streptomyceten. III. Einbau von D-Glucose-u-14C in Paromomycin als Indikator für die Antibioticabildung durch Streptomyces albus var. metamycinus nov. var.

✍ Scribed by H. Köster; B. Liebermann; Prof. Dr. G. Reuter

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 527 KB
Volume: 15
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19750150607

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✦ Synopsis

Abstract

Paromomycin was isolated from culture filtrates of Streptomyces albus var. metamycinus nov. var. after feeding the growing cultures with D‐glucose‐u‐^14^C. From the different incorporation rates conclusions concerning different features of the paromomycin biosynthesis (utilization of the carbon source, proportional and disproportional changes of the rates of synthesis) could be drawn. Uptake and metabolism of glucose are discussed.

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✍ Prof. Dr. G. Reuter; H. Köster; B. Liebermann 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB

## Abstract Distribution of radioactivity in paromomycin ascertained after application of ^14^C‐D‐glucose, ^14^C‐D‐glucosamine, ^14^C‐2‐deoxystreptamine, respectively, ^14^C‐D‐ribose is taken as basis for a biosynthesis scheme: While ribose bound in the antibiotic originates from glucose by oxidati