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Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules

โœ Scribed by Peter Thygesen; Panos Macheras; Achiel Van Peer

Publisher
Springer US
Year
2009
Tongue
English
Weight
224 KB
Volume
26
Category
Article
ISSN
0724-8741

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๐Ÿ“œ SIMILAR VOLUMES

The pharmacology of PEGylation: Balancin
The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics
โœ C. Simone Fishburn ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 351 KB

Conjugation of macromolecules to polyethylene glycol (PEG) has emerged recently as an effective strategy to alter the pharmacokinetic (PK) profiles of a variety of drugs, and thereby to improve their therapeutic potential. PEG conjugation increases retention of drugs in the circulation by protecting