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Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution

✍ Scribed by Max von Kleist; Wilhelm Huisinga

Publisher
Springer
Year
2007
Tongue
English
Weight
424 KB
Volume
34
Category
Article
ISSN
1573-8744

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Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions
✍ Trudy Rodgers; Malcolm Rowland πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 269 KB

A key component of whole body physiologically based pharmacokinetic (WBPBPK) models is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of Kpu values using mechanistically derived equations has been investigated for 7 very weak bases, 20 acids, 4 neutral drugs and 8 zwit