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Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats

✍ Scribed by Jessica L. Matthews; Irvin R. Schultz; Michael R. Easterling; Ronald L. Melnick

Book ID
113924686
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
964 KB
Volume
244
Category
Article
ISSN
0041-008X

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Physiologically based pharmacokinetic mo
Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim