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Physiological stress and nerve growth factor treatment regulate stress-activated protein kinase activity in PC12 cells

✍ Scribed by Goodman, M. Nadine ;Reigh, Clint W. ;Landreth, Gary E.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
203 KB
Volume
36
Category
Article
ISSN
0022-3034

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✦ Synopsis

The stress-activated protein kinases posure to cellular stressors provoked a proportion-(SAPKs) are differentially activated by a variety of ately smaller stimulation of SAPK activity than that cellular stressors in PC12 cells. SAPK activation has observed in naive cells, despite the presence of much been linked to the induction of apoptotic cell death higher levels of SAPK protein. The insensitivity of upon serum withdrawal from undifferentiated cells or SAPK to activation by stressors was reflective of the following nerve growth factor (NGF) withdrawal of activity of the SAPK activator SEK, whose activation neuronally differentiated PC12 cells. However, withwas also diminished following NGF differentiation of drawal of trophic support from differentiated cells led the cells. The data demonstrate that SAPKs are subto only a very modest elevation of SAPK activity and ject to complex controls through both induction of led us to investigate the basis of the relative insensitiv-SAPK expression and the regulation mediated by ity of these enzymes to stressors. NGF-stimulated difupstream elements within this pathway. ᭧ 1998 John ferentiation of the cells resulted in the elevation of

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