Physiological flow model for drug elimination interactions in the rat
โ Scribed by Richard H. Luecke; Lynn E. Thomason; Walter D. Wosilait
- Publisher
- Elsevier Science
- Year
- 1980
- Weight
- 681 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0010-468X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The kinetics of hepatic elimination of the high-clearance drug propranolol has been interpreted in a previous study from our laboratory, in which propranolol protein binding was varied, to conform to the venous equilibrium model. In another study by a different group, in which perfusate flow was var
Brevican is one of the most abundant chondroitin sulfate proteoglycans in the adult rat brain. We have recently shown that the C-type lectin domain of brevican binds fibronectin type III domains 3-5 of tenascin-R. Here we report strong evidence for a physiological basis for this interaction. Substan