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Physiological and pathological implications of semicarbazide-sensitive amine oxidase

✍ Scribed by Peter H Yu; Shannon Wright; Ellen H Fan; Zhao-Rong Lun; Diana Gubisne-Harberle


Book ID
108497859
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
179 KB
Volume
1647
Category
Article
ISSN
1570-9639

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Several organosilicon amines were synthesized as potential mechanism-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) prepared from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]methanamine, hydrochloride produced potent time-dependent inhibition of SSAO. A potential mechanism is propos