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Physiological and pathological functions of P2X7 receptor in the spinal cord

โœ Scribed by Maria Luisa Cotrina; Maiken Nedergaard


Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
213 KB
Volume
5
Category
Article
ISSN
1573-9538

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We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a