## Abstract Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X~7~ subtype is unique in that it can function as a cation channel, a nonselective pore, or even a signaling complex coupled with multiple downstream components. Several roles of P2X~7~ receptors have
Genetic polymorphisms of the human P2X7 receptor and relationship to function
β Scribed by James S. Wiley; Ben J. Gu; Weiyi Zhang; Rebecca A. Worthington; Phuong Dao-Ung; Anne N. Shemon; Ronald Sluyter; Simon Liang; Julian A. Barden
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 175 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0272-4391
- DOI
- 10.1002/ddr.1173
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Polyclonal antisera generated to peptides corresponding to the carboxy termini of the seven cloned rat P2X receptors were compared using membranes from CHO-K1 or 1321N1 cells expressing recombinant rat or human P2X receptors (rat P2X 3 , P2X 4 , and P2X 5 and human P2X 1 , P2X 2 , P2X 6 , and P2X 7