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Physicochemical property modification strategies based on enzyme substrate specificities I: Rationale, synthesis, and pharmaceutical properties of aspirin derivatives

✍ Scribed by Pradip K. Banerjee; Gordon L. Amidon

Book ID: 102915360
Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 582 KB
Volume: 70
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600701202

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The aspirin derivatives aspirin phenylalanine and aspirin phenyllactic acid were studied as substrates for carboxypeptidase A. The phenyllactic acid derivative (an ester) was the best substrate but showed considerable product inhibition. The kinetic parameters for both substrates were in the range e