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Physicochemical property modification strategies based on enzyme substrate specificities II: α-chymotrypsin hydrolysis of aspirin derivatives

✍ Scribed by Pradip K. Banerjee; Gordon L. Amidon

Book ID
102405537
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
287 KB
Volume
70
Category
Article
ISSN
0022-3549

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Physicochemical property modification st
Physicochemical property modification strategies based on enzyme substrate specificities III: Carboxypeptidase a hydrolysis of aspirin derivatives
✍ Pradip K. Banerjee; Gordon L. Amidon 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB

The aspirin derivatives aspirin phenylalanine and aspirin phenyllactic acid were studied as substrates for carboxypeptidase A. The phenyllactic acid derivative (an ester) was the best substrate but showed considerable product inhibition. The kinetic parameters for both substrates were in the range e