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Physicochemical characterization of spray-dried phenylbutazone polymorphs

✍ Scribed by Yoshihisa Matsuda; Sachiyo Kawaguchi; Hitomi Kobayashi; Jujiro Nishijo

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 767 KB
Volume: 73
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600730209

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✦ Synopsis

A spray-drying method was applied to the recrystallization of phenylbutazone, and the resulting samples were examined by X-ray powder diffractometry, differential thermal analysis, IR spectrophotometry, scanning electron microscopy, and hot-stage photomicroscopy.

Three different crystalline forms (8, fl, and c) could be prepared from methylene chloride solution by varying the drying temperature of sprayed droplets from 120°C to 30OC. Form c, the fifth polymorph of phenylbutazone, was confirmed as a novel crystalline form which could not be prepared by recrystallization techniques. In this spray-drying system the composition of spray-dried samples was shown to be a function of the drying temperature. While the stable form b was obtained a t higher

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