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Physicochemical characterization of a new respirable form of nedocromil

✍ Scribed by Hak-Kim Chan; Igor Gonda

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 573 KB
Volume: 84
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600840606

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✦ Synopsis

Elongated, respirable particles of nedocromil were prepared by its crystallization from N-methyl-2-pyrrolidone (NMP) obtained from an aqueous solution of its sodium salt by precipitation with hydrochloric acid. Aerosols of these particles were recently generated and characterized for their aerodynamic properties (Chan, H.-K.; Gonda, I. J. Aerosol Med. 1993, 6, 241-249). This paper reports the physiochemical properties of the solid form of nedocromil as characterized by polarizing optical and scanning electron microscopies, thermal analysis (DSC, TGA), X-ray powder diffraction, water vapor adsorption isotherms, mass spectrometry, solid state Fourier transform IR and solution 1H-NMR spectroscopies.

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