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Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines

✍ Scribed by Liang Fang; Sachihiko Numajiri; Daisuke Kobayashi; Hideo Ueda; Koji Nakayama; Hiroshi Miyamae; Yasunori Morimoto

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
348 KB
Volume
93
Category
Article
ISSN
0022-3549

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✦ Synopsis

The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray crystallographic studies demonstrated that MH and each alkanolamine formed an ion pair complex. The series of amine complexes had a lower melting point and higher solubility in water compared with pure MH.

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