Synthesis, Physicochemical Characterization, and Cytotoxic Screening of New Zirconium Complexes with Coumarin Derivatives

✍ Scribed by Irena Kostova; Ilia Manolov; Margarita Karaivanova

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 80 KB
• Volume: 334
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/1521-4184(200105)334:5<157::aid-ardp157>3.0.co;2-s

✦ Synopsis

Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR-spectroscopy, 1H-NMR spectroscopy, and thermal studies. Differential thermal analyses and thermogravimetric analyses have been applied to study the compositions of the new complexes. It is concluded that the lactone- and the keto-carbonyl groups of warfarin, coumachlor, and niffcoumar are bonded to the metal ion as bidentate ligands, but mendiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT-assay was carried out. Among these compounds the zirconium complex of mendiaxon showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. The inorganic salt was found to be active against this cell line.