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Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

โœ Scribed by Brownh, Peter D.; Wakefiel, Lalage M.; Levinson, Arthur D.; Sporn, Michael B.


Book ID
115547746
Publisher
Informa plc
Year
1990
Tongue
English
Weight
650 KB
Volume
3
Category
Article
ISSN
0897-7194

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Transforming growth factor-b (TGF-b) is normally secreted in a latent form, and plasmin-mediated proteolytic cleavage of latency-associated peptide (LAP), a component of latent TGF-b complex that makes the complex inactive, activates latent TGF-b. In the present study, we investigated the possible i