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Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins

✍ Scribed by R.Garcia Domenech; O.Abril Mendez; J.Galvez Alvarez; A.Farga Marti

Publisher: Elsevier Science
Year: 1989
Weight: 170 KB
Volume: 40
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(89)90141-x

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✦ Synopsis

This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.

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