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Physical properties of hyaluronic acid and hydroxypropylmethylcellulose in solution: Evaluation of coating ability

✍ Scribed by Frederick H. Silver; Joseph LiBrizzi; George Pins; Ming-Che Wang; Dominick Benedetto

Publisher
Wiley (John Wiley & Sons)
Year
1994
Tongue
English
Weight
755 KB
Volume
5
Category
Article
ISSN
1045-4861

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✦ Synopsis

Hyaluronic acid (HA) and hydroxypropylmethylcellulose (HPMC) in buffered saline are "viscoelastics" used in ophthalmic surgery to prevent mechanical damage to delicate eye structures and to form a protective coating over corneal endothelium.

HA is a high molecular weight polysaccharide that exhibits decreasing viscosity at increased shear rates. HPMC is a cellulose derivative that exhibits low surface tension. This study examines the physical properties of HA and HPMC solutions and attempts to correlate these properties with the ability of those macromolecules to coat and protect ocular structures.

Results presented in this article suggest mixtures of HA and HPMC exhibit low surface tension and ease of aspiration characteristics that are desired in viscoelastic materials. For this reason a blend of these two macromoleculars offers handling advantages over each of these individual macromolecules.

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