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Physical Properties of Hemoglobin Vesicles as Red Cell Substitutes

โœ Scribed by Hiromi Sakai; Kenichi Hamada; Shinji Takeoka; Hiroyuki Nishide; Eishun Tsuchida


Book ID
109387819
Publisher
American Institute of Chemical Engineers
Year
1996
Tongue
English
Weight
177 KB
Volume
12
Category
Article
ISSN
8756-7938

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โœ Hiromi Sakai; Kenichi Hamada; Shinji Takeoka; Hiroyuki Nishide; Eishun Tsuchida ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 615 KB

The two kinds of red cell substitutes, hemoglobin-vesicles (HbV) and lipidheme-vesicles (LihV, totally synthetic oxygen carrier), were evaluated in terms of physicochemical properties suck as binding and dissociating reactions of ligands (CO, 0, and NO), rheological and structural properties. Carbon

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Long-term preservation of hemoglobin (Hb) vesicles, the so-called artificial red cell (ARC), in dry powder was studied. Carbonylhemoglobin (COHb) was encapsulated in the vesicle of 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phosphocholine (DODPC) and the polymerizable membrane components were polymer

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Phospholipid vesicles encapsulating purified hemoglobin [Hb vesicles (HbV); diameter 259 ยฑ 82 mm; oxygen affinity 31 mm Hg; [Hb] 5 and 10 g/dL] were developed to provide oxygen-carrying capacity to plasma expanders. Their function as a blood replacement was tested in the subcutaneous microvasculatur