Physical mapping of 12q13–q15 translocation region in uterine leiomyoma with classical t(12; 14)
✍ Scribed by E. Schoenmakers; S. Wanschura; B. Kazmierczak; C. Huysmans; H. Van den Berghe; J. Bullerdiek; W. Van de Ven
- Book ID
- 113253841
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 160 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0165-4608
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Uterine leiomyoma is the most common tumor of smooth muscle cell origin and is often associated with the recurrent balanced translocation t( 12; I4)(q I 3-I5;q24). As an initial step toward finding the gene or genes that are interrupted by the translocation breakpoint, a somatic cell hybrid carrying
## Abstract A substantial percentage of uterine leiomyomas are cytogenetically characterized by consistent, clonal chromosome abnormalities, including t(12;14)(q14–15;q23–24) and other rearrangements of 12q14–15 that occur without any visible 14q changes. The partly similar banding characteristics