Physical mapping of 12q13–q15 translocation breakpoints of primary pleomorphic adenomas of the salivary glands, uterine leiomyomas, lipomas and derived cell lines
✍ Scribed by S. Wanschura; G. Belge; G. Stenman; E. Schoenmakers; P. Dal Cin; S. Bartnitzke; H. Van den Berghe; W. Van de Ven; J. Bullerdiek
- Book ID
- 113253843
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 160 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Cytogenetic aberrations involving 12q13‐15 are frequently observed in a variety of benign solid tumors. Using a chromosome walking approach combined with fluorescence in situ hybridization analysis, we were able to show that the chromosome 12 breakpoints involved in uterine leiomyoma, p
The transcription factor gene CHOP was recently shown to be rearranged in myxoid liposarcoma with t( 12; I6)(q I );p I I). We have analyzed whether the CHOP gene is the target of rearrangements in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses with chromosome abnormalities of
Uterine leiomyoma is the most common tumor of smooth muscle cell origin and is often associated with the recurrent balanced translocation t( 12; I4)(q I 3-I5;q24). As an initial step toward finding the gene or genes that are interrupted by the translocation breakpoint, a somatic cell hybrid carrying