Physical linkage of variable, diversity and joining gene segments in the immunoglobulin heavy chain locus of the mouse
β Scribed by Thomas Christoph; Ulrich Krawinkel
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 899 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0014-2980
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During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear
## Abstract Abnormalities of immunoglobulin (Ig) heavy chain synthesis occurring in human B lymphoid cell lines of malignant origin suggest that the Ig heavyβchain gene complex is involved in the 8:14 chromosome translocation which these cells carry.