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Physical linkage of variable, diversity and joining gene segments in the immunoglobulin heavy chain locus of the mouse

✍ Scribed by Thomas Christoph; Ulrich Krawinkel


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
899 KB
Volume
19
Category
Article
ISSN
0014-2980

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During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear

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## Abstract Abnormalities of immunoglobulin (Ig) heavy chain synthesis occurring in human B lymphoid cell lines of malignant origin suggest that the Ig heavy‐chain gene complex is involved in the 8:14 chromosome translocation which these cells carry.