During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear
Evidence for involvement of the immunoglobulin heavy-chain gene locus in the 8:14 translocation of human B lymphomas
โ Scribed by R. V. McIntosh; B. B. Cohen; C. M. Steel; Helene Read; Marion Moxley; H. J. Evans
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 509 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Abnormalities of immunoglobulin (Ig) heavy chain synthesis occurring in human B lymphoid cell lines of malignant origin suggest that the Ig heavyโchain gene complex is involved in the 8:14 chromosome translocation which these cells carry.
๐ SIMILAR VOLUMES
A study was performed to investigate the utility of polymerase chain reaction (PCR)-based analysis of immunoglobulin heavy chain (IgH) gene rearrangements for the diagnosis of low-grade malignant B-cell lymphomas on formalin-ยฎxed, EDTA-decalciยฎed, and parafยฎn-embedded bone marrow trephine biopsies.
We describe a t(8; I4)(q24;q I I) involving the T-cell receptor a-chain gene (TCRA) and the 3' region of the MYC protooncogene in a B-cell lymphoma. The 6-cell origin of this tumor was determined by its histological architecture, by immunophenotypic analysis, and by Southern analysis of immunoglobul
## BACKGROUND. The demonstration of the monoclonality of immunoglobulin heavy chain (IgH) gene rearrangement is an indispensable method for the diagnosis of B-cell lymphoma as well as histocytochemical analysis. For the detection of IgH gene rearrangement, the extraction of DNA from a homogenous c
The t(14;18)(q32;q21) translocation, involving the BCL2 gene and junctional segments (J H ) of the immunoglobulin heavy chain gene (IGH), constitutes the most common chromosomal translocation in non-Hodgkin's lymphoma of B-cell type. Although the breakpoints in BCL2 are largely clustered within the