Physical linkage of two mammalian imprinted genes, H19 and insulin–like growth factor 2
✍ Scribed by Zemel, Sharon; Bartolomei, Marisa S.; Tilghman, Shirley M.
- Book ID
- 109916880
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 743 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1061-4036
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## BACKGROUND. Insulin-like growth factor-2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed maternally. Loss of imprinting (LOI) at both H19 and IGF2 has been reported in seven fully informative adult testicular germ cell tumors (
## Abstract This study examined the frequency of loss of imprinting (LOI) and expression of the insulin‐like growth factor 2 (__IGF2__) gene, and their relationship to selected clinical and pathological factors, in a well defined series of 90 Chinese patients with gastric cancer (GC) and 90 matched