Physical stability of salts of weak base
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Gregory A. Stephenson; Aktham Aburub; Timothy A. Woods
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Article
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2011
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John Wiley and Sons
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English
β 377 KB
When selecting the physical form of an active pharmaceutical substance, there is often a question of when a molecule's pKa renders it too low for salt formation and formulation into a product that will be sufficiently physically stable to provide adequate shelf life. In the paper, a graph is provide