Physical and chemical factors influencing the release of drugs from acrylic resin films
β Scribed by Michelle R. Jenquin; Stephen M. Liebowitz; Rafael E. Sarabia; James W. McGinity
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 687 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer
This aper is the second of a series on Clinical Equivalency. See Re$renccs 1 and 2 for the first and third papers. The authors thank Ur. A. W. Kinkel and Ur. 13. Holmes for the human absorption data shown in Fig. 5 ; Miss B. Shawler for assistance in the dissolution measurements; and Dr. J. F. Sadus