Evaluation of physical and pharmaceutical factors involved in drug release and availability from chloramphenicol capsules

✍ Scribed by A. J. Aguiar; L. M. Wheeler; S. Fusari; J. E. Zelmer

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 725 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600571104

✦ Synopsis

This aper is the second of a series on Clinical Equivalency. See Re$renccs 1 and 2 for the first and third papers. The authors thank Ur. A. W. Kinkel and Ur. 13. Holmes for the human absorption data shown in Fig. 5 ; Miss B. Shawler for assistance in the dissolution measurements; and Dr. J. F. Sadusk and Dr. L. M. Lueck for their constructive suggestions during the course of this work. EXPERIMENTAL The capsules tested were four commercial lots of chloramphenicol capsules produced by different manufacturers and were purchased from a local