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Physeal reconstruction using tissue donated from early postnatal limbs in a murine model

✍ Scribed by Peter J. Cundy; Michael Jofe; David J. Zaleske; Michael G. Ehrlich; Henry J. Mankin

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 644 KB
Volume: 9
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100090307

No coin nor oath required. For personal study only.

✦ Synopsis

Physeal reconstruction was performed in a murine model by transplanting corresponding postnatal tissue from 4-day-old C57B mice to resection defects. The site of the reconstruction, the murine distal femoral epiphysis, is completely cartilaginous and avascular at this stage of development. The tissue transplanted into the defect was demonstrated to have high kinetic activity by its incorporation of tritiated thymidine. The physeal reconstruction as performed restored only 25% of normal growth. While transplanting cell populations is feasible, the method will require a great deal of work before clinical application.

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Hemiepiphyseal reconstruction using tissue donated from fetal limbs in a murine model

✍ Michael J. Wolohan; Dr. David J. Zaleske 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 523 KB

## Abstract Epiphyseal reconstruction in the immature skeleton could have great clinical significance. Hemiepiphyseal reconstruction was performed in a murine model by transplanting fetal tissue to surgically created defects in postnatal mice. Reconstruction is facilitated by the existence of inbre