✦ LIBER ✦

Hemiepiphyseal reconstruction using tissue donated from fetal limbs in a murine model

✍ Scribed by Michael J. Wolohan; Dr. David J. Zaleske

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 523 KB
Volume: 9
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100090205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Epiphyseal reconstruction in the immature skeleton could have great clinical significance. Hemiepiphyseal reconstruction was performed in a murine model by transplanting fetal tissue to surgically created defects in postnatal mice. Reconstruction is facilitated by the existence of inbred strains. While the reconstruction as performed here did not completely restore the growth characteristics of the epiphysis, the model represents a potentially fruitful interface between basic and clinical biology.

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Physeal reconstruction was performed in a murine model by transplanting corresponding postnatal tissue from 4-day-old C57B mice to resection defects. The site of the reconstruction, the murine distal femoral epiphysis, is completely cartilaginous and avascular at this stage of development. The tissu