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Phthalocyanine photophysics and photosensitizer efficiency on human embryonic lung fibroblasts

✍ Scribed by John W. Owens; Marsha Robins

Book ID
102398850
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
73 KB
Volume
05
Category
Article
ISSN
1088-4246

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✦ Synopsis

This study correlates the photophysical properties of aluminum phthalocyanine tetrasulfonate (AlPcTs), zinc phthalocyanine tetrasulfonate (ZnPcTs), and phthalocyanine tetrasulfonate (PcTs) with their ability to kill human embryonic lung (HEL) cells. Photofrin, a proven anti-cancer drug, was used for comparison. The photophysical properties include fluorescence emission spectra, fluorescence quantum yields, singlet state and radiative lifetimes, quantum yield for triplet formation, and fluorescence rate constants. Results indicate that photodynamic efficacy correlates inversely with fluorescence quantum yield and fluorescence lifetime and directly with quantum yield for triplet formation.

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