Phthalocyanine 4 (Pc 4) Photodynamic Therapy of Human OVCAR-3 Tumor Xenografts
โ Scribed by Valdir C. Colussi; Denise K. Feyes; John W. Mulvihill; Ying-Syi Li; Malcolm E. Kenney; Craig A. Elmets; Nancy L. Oleinick; Hasan Mukhtar
- Book ID
- 111412553
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 700 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0031-8655
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๐ SIMILAR VOLUMES
## Abstract ## Background and Objectives As a potential therapy for malignant glioma, we tested the phthalocyanine photosensitizer Pc 4 for: (1) rapid clearance from the vasculature, (2) specificity for glioma, and (3) tumoricidal photosensitizing capability. ## Study Design/Materials and Methods
Background: Photodynamic therapy (PDT) is a non-invasive treatment for non-melanoma skin cancer. However, PDT systems currently used clinically have limitations such as painand superficial tissue penetration. The silicon phthalocyanine Pc 4 is a second-generation photosensitizer with peak absorption