𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Phototoxicity induced by nalidixic and oxolinic acids: Decrease in cell survival of chick embryo fibroblasts and Hep-2 cells

✍ Scribed by M.P. Cortés; A.M. Cárdenas; E. Navarrete; E. Fernández

Book ID
103993256
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
334 KB
Volume
9
Category
Article
ISSN
1011-1344

No coin nor oath required. For personal study only.

✦ Synopsis

The phototoxic effects of nalidixic and oxolinic acids were evaluated in two types of cultured cells: chick embryo fibroblast and Hep-2 (human laryngo carcinoma cell line). In order to evaluate the phototoxicity induced by nalidixic and oxolinic acids, both cell types were irradiated for 5 min in the presence of each drug. The results showed an inverse relationship between cell survival and the concentration of the drug added to the culture medium. The concentrations of nalidixic and oxolinic acids necessary to induce a phototoxic effect were in the range of therapeutic blood levels. Both chick embryo fibroblasts and Hep-2 cells were more sensitive to the phototoxic effect induced by nalidixic acid than oxolinic acid.

📜 SIMILAR VOLUMES

Decreased heme content and cessation of
Decreased heme content and cessation of cell growth in cultured chick embryo fibroblasts in the presence of horse serum: Stimulation of heme synthesis and cell growth by iron
✍ Claude Verger; José Imbenotte 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract A new spectrofluorometric method for heme quantitation in cultured fibroblasts is described. The method includes: (1) heme extraction by methanol/sulfuric acid, (2) partial purification of heme by a microchromatographic method, and (3) treatment of the purified heme by oxalic acid follo

Suppression of fibroblast growth factor
Suppression of fibroblast growth factor 2 expression by antisense oligonucleotides inhibits embryonic chick neural retina cell differentiation and survival in vivo
✍ Laurent Désiré; Mark W. Head; Nicole A. Fayein; Yves Courtois; Jean-Claude Jeann 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 398 KB 👁 3 views

During retinal differentiation, fibroblast growth factor 2 (FGF2) expression increases in retinal neurons following the sequential appearance of the neuronal layers. The function of the developmental increase of endogenous FGF2 in the developing chick retina was investigated by using an antisense st

Peroxisome proliferation, adipocyte dete
Peroxisome proliferation, adipocyte determination and differentiation of C3H10T1/2 fibroblast cells induced by humic acid: Induction of PPAR in diverse cells
✍ Yashang Lee; Tien-Shang Huang; Mei-Ling Yang; Lan-Ru Huang; Ching-Hsein Chen; Fu 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB 👁 1 views

Humic acid, a high-molecular-weight polyphenolic compound, exists abundantly in soil, natural water, and various terrestrial and aquatic environments. Humic acid causes peroxisome proliferation in mouse liver and induces the expression of peroxisome proliferator activated receptor (PPAR) in BNL CL.2