Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds
✍ Scribed by Phong V. Pham; David A. Nagib; Prof. David W. C. MacMillan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 472 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
## Abstract A new photoredox‐based method for the α‐trifluoromethylation of carbonyl compounds and enolsilanes is accomplished.
The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient con
The development of CÀC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan