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PHOTOLABILE MULTI-DETACHABLE p-ALKOXYBENZYL ALCOHOL RESIN SUPPORTS FOR PEPTIDE FRAGMENT OR SEMI-SYNTHESIS

โœ Scribed by TAM, JAMES P. ;DIMARCHI, RICHARD D. ;MERRIFIELD, R.B.


Book ID
115097671
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
920 KB
Volume
16
Category
Article
ISSN
0367-8377

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Multi-detachable resin supports for soli
โœ James P. Tam; Foe S. Tjoeng; R.B. Merrifield ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 255 KB

Two multi-detachable resin supports, each containing orthogonally removable benzyl and photolabile esters were prepared and applied to the synthesis of Leu-enkephalin and angiotensin. These resins, called Pop and Pon, could be cleaved by acid to give the free peptide, by nucleophiles to give protect