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Photogenotoxicity of Fluoroquinolones in Chinese Hamster V79 Cells: Dependency on Active Topoisomerase II

✍ Scribed by Ronald D. Snyder; Curt S. Cooper

Book ID
111412560
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
623 KB
Volume
69
Category
Article
ISSN
0031-8655

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Determination of the clastogenic potential of new chemical entities, particularly pharmaceuticals, is an important part of the overall safety assessment of such drugs. It is appreciated that clastogenicity can arise from perturbation of many different cellular processes distinct from direct DNA/drug