𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Photofrin II localization in rat cecum

✍ Scribed by David J. Bjorkman; Earl J. Brigham; Brian J. Peterson; Richard C. Straight

Book ID
102466446
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
332 KB
Volume
9
Category
Article
ISSN
0196-8092

No coin nor oath required. For personal study only.

✦ Synopsis

Laser excitation of photodynamic agents localizing in colonic tumors may allow the early diagnosis and treatment of colon cancer. The efficacy of these agents requires a high ratio of tumor to background photosensitizer accumulation and fluorescence. To assess normal colonic background fluorescence and hematoporphyrin accumulation 31 rats were studied after an intravenous injection of Photofrin I1 (PF-11) at a dose of 5 mg/kg. An increase in mucosal fluorescence and porphyrin content was noted in the cecum 24 hours after injection.

Cecal accumulation of PF-I1 may affect its efficacy in the localization and treatment of cecal tumors. Further investigation into the mechanism and clinical significance of this finding is needed.

πŸ“œ SIMILAR VOLUMES

Photoproducts formed from photofrin II i
Photoproducts formed from photofrin II in cells
✍ Johan Moan; David Kessel πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 English βš– 488 KB

Fluorescence and absorption spectra of light-exposed cells containing the tumour-localizing porphyrin preparation Photofrin II (PII) have been studied. Light exposure results in spectral changes that may be due to a photoinduced modification of the porphyrins without breakage of the porphyrin macroc

DISTRIBUTION AND ELIMINATION OF PHOTOFRI
DISTRIBUTION AND ELIMINATION OF PHOTOFRIN II IN MICE
✍ David A. Bellnier; Yau-Kwan Ho; Ravindra K. Pandey; Joseph R. Missert; Thomas J. πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 696 KB
Photophysical properties of Photofrin II
Photophysical properties of Photofrin II in different solvents
✍ A. Andreoni; R. Cubeddu πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 English βš– 329 KB

The photophysical properties of Photofrin II are studied in water, methanol nnd tetrahydrofurm solurions and compared with those of hematoporphyrin. Time-resolved fluorescence measurements indicate rhc presence in terrahydrofurar! solutions of Pbotofrin II of a new decay component with time constant

Carrier thiols are targets of photofrin
Carrier thiols are targets of photofrin II photosensitization of isolated rat liver mitochondria
✍ A. Atlante; S. Passarella; E. Quagliariello; G. Moreno; C. Salet πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 English βš– 869 KB

To gain further insight into the ability of Photofrin II to photosensitize mitochondrial translocators, and to ascertain whether mitochondrial thiols are specific targets of Photofrin II, the activity of phosphate carrier was measured in isolated rat liver mitochondria irradiated with 365 nm light i

Peritoneal adhesion formation in a rat c
Peritoneal adhesion formation in a rat cecum model
✍ FD Yelian; R Khalifa; K Oomen; MP Diamond πŸ“‚ Article πŸ“… 1998 πŸ› American Association of Gynecologic Laparoscopists 🌐 English βš– 103 KB