Photodynamic therapy/oncology

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 82 KB
• Volume: 32
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.1154

✦ Synopsis

Background and Objective: We used single photon emission computed tomography (SPECT) brain perfusion imaging to study the changes of regional cerebral blood flow (rCBF) and cerebral function in brain infarction patients treating with intravascular laser irradiation of blood (ILIB). Study Design/Materials and Methods: 17 of 35 patients with brain infarction were treated by ILIB on the base of standard drug therapy, and SPECT brain perfusion imaging was performed before and after ILIB therapy with self-comparison. The results were analyzed in quantity with BFCR% model. Effect of ILIB during the therapy process in the other 18 patients were also observed. Results: In the 18 patients, SPECT indicated a improvement of rCBF (both in focus and in total brain) and cerebral function after a 30 min-ILIB therapy. And the 17 patients showed an enhancement of total brain rCBF and cerebral function after ILIB therapy in comparison with that before, especially for the focus side of the brain. The enhancement for focus itself was extremely obvious with a higher significant difference (P < 0.0001). The mirror regions had no significant change (P > 0.05). BFCR% of foci was prominently higher than that of mirror regions (P < 0.0001). Conclusions: The ILIB therapy can improve rCBF and cerebral function and activate brain cells of patients with brain infarction. The results denote new evidence of ILIB therapy for those patients with cerebral ischemia.