✦ LIBER ✦

Photodynamic therapy/oncology

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 94 KB
Volume: 36
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.20171

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✦ Synopsis

Introduction:

The aim of this study has been to study the behaviour of L-Citrulina like a marker on induced arthritis in rats treated with rofecoxib and HeNe laser irradiation. Material and Methods: 2 mg of hidroxiapatita (HP) were injected in both joints of the lower limbs of rats during 3 days. Rats were assigned in 4 different groups: Group 1: control Group 2: rats with induced arthritis (untreated arthritis) Group 3: rats with induced arthritis and irradiated with He-Ne (7 mW) Group 4: rats with induced arthritis and treated with Rofecoxib (0.05 mg/day/rat). The laser irradiations were carried out daily on the joints to the 24, 48 and 72 hs. the same as the treatment with rofecoxib. L-Citruline was determined by spectophotometry. Results: a statistically significant increase (p < 0.01) in the L-Citruline levels (6.52 AE 0.44 mM) was observed in the group injected with HP (Group 2) when compared with the control group (Group 1) (3.58 AE 0.22 mM.). We found no significant decrease in the Plasmatic levels of L-Citruline between the untreated arthritis group (Group 2) and the Rofecoxib group (Group 4) (5.38 AE 0.28 mM). A significant difference (p < 0.01) were found when compared the group irradiated with laser (Group 3) versus the induced arthritis group (Group 2). Conclusions: These results suggest that the irradiation with HeNe laser has an inhibitory effect in the plasmatic levels of L-Citruline in induced microcrystalline arthritis in rats.

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