## Background and Objective : The reactive oxygen mechanisms associated with cell damage after photodynamic therapy (PDT) may be exploited to enhance tumor destruction. Pharmacological reduction of glutathione (GSH), an inhibitor of reactive oxygen species, can be induced by administration of buth
Photodynamic therapy with photofrin in combination with Buthionine Sulfoximine (BSO) of human glioma in the nude rat
β Scribed by F. Jiang; A. M. Robin; M. Katakowski; L. Tong; M. Espiritu; G. Singh; M. Chopp
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 327 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0268-8921
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Background and objective: Liposomes as photosensitizer carriers may enhance the photodynamic effect on tumors. ## Study design/materials and methods: To test this hypothesis, we treated u87 human glioma in rat brain with photodynamic therapy (pdt) using photofrin encapsulated in a liposome car
## Abstract ## Background and Objectives As a potential therapy for malignant glioma, we tested the phthalocyanine photosensitizer Pc 4 for: (1) rapid clearance from the vasculature, (2) specificity for glioma, and (3) tumoricidal photosensitizing capability. ## Study Design/Materials and Methods
## Abstract The widespread acceptance of photodynamic therapy (PDT), a potential adjuvant brain tumor therapy under clinical evaluation since 1980, has been partially restrained by its potential toxicity toward normal brain tissue. This study examined PDTβproduced injury of normal rat brain as a fu