Endoscopic photodynamic therapy (PDT) with haematoporphyrin derivative was used in the primary treatment of 69 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups: 31 with oesophageal squamous cell carcinoma, 17 with adenocarcinoma of the stomach or lower thi
Photodynamic therapy with derivatives of haematoporphyrin and tetraphenylporphine
✍ Scribed by David Kessel
- Book ID
- 110573897
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 351 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0268-8921
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A case-control photodynamic therapy (PDT) was studied on adenocarcinoma (AC755) in BDF1 mice. Haematoporphyrin derivative (HPD; Porphyrin Products, U.S.A.) and a Bulgarian HPD were used as photosensitizers at doses of 10 mg kg-1. An argon dye laser system with lambda em=630 nm (400 mW cm-2) was used
Conjugates of haematoporphyrin (HP) with serum albumin and transferrin were prepared, purified by gel filtration and characterized by high performance liquid chromatography (HPLC), polyacrylamide gel electrophoresis (PAGE) and spectroscopy. Although the fluorescence was somewhat quenched, the conjug