Endoscopic photodynamic therapy with haematoporphyrin derivative in gastroenterology

✍ Scribed by T. Patrice; M.T. Foultier; S. Yactayo; M.C. Douet; F. Maloisel; L. Le Bodic

• Book ID: 103993085
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 367 KB
• Volume: 6
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/1011-1344(90)85085-b

✦ Synopsis

Endoscopic photodynamic therapy (PDT) with haematoporphyrin derivative was used in the primary treatment of 69 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups: 31 with oesophageal squamous cell carcinoma, 17 with adenocarcinoma of the stomach or lower third of the oesophagus and 21 with rectosigmoid adenocarcinoma. After infusion of 2.5-5.0 mg haematoporphyrin derivative per kilogram of body weight, lesions were irradiated using an argon dye laser (632 nm). During a follow-up period averaging 20 months (27.9 months for 35 surviving patients), complete local tumour destruction and negative histology were observed in 32 out of 69 cases. Flow-cytometric analysis of DNA content before and after PDT suggests that a clonal selection occurs in some cases of treatment failure. The results of this open pilot study suggest the potential efficacy of PDT as a curative treatment for selected cases of inoperable gastrointestinal cancers.