Photodynamic therapy with chlorin e6 for skin metastases of melanoma
β Scribed by Sergey V. Sheleg; Edvard A. Zhavrid; Tatsiana V. Khodina; Georgy A. Kochubeev; Yury P. Istomin; Vadim N. Chalov; Ivan N. Zhuravkin
- Book ID
- 111262880
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 299 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0905-4383
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Chlorin e6 ( Ce 6) was conjugated with anti-tumor monoclonal antibody ( IgG 2 b ) to increase its binding affinity for tumors. The Ce 6 was activated by N -hydroxysuccinimide and directly conjugated with IgG 2 b ( IgG 2 b β Ce 6) via peptide bonds. An average of 11 Ce 6 molecules were coupled to eac
Morphological changes in rat sarcoma M-1 after photodynamic treatment with chlorin e6 were studied. The frequency of necrosis appearance and the depth of its spreading in tumor tissue were evaluated after intraperitoneal injection of chlorin e6 in doses of 1-10 mg kg-1 and subsequent irradiation by