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34 Lipophilic derivatives of chlorin e6 as novel tools for photodynamic therapy

✍ Scribed by Ponomarev, G.V.; Solovieva, M.N.; Dugin, N.O.; Mehtiev, A.R.; Misharin, A.Yu.

Book ID
123272461
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
53 KB
Volume
9
Category
Article
ISSN
1572-1000

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Chlorin e6 ( Ce 6) was conjugated with anti-tumor monoclonal antibody ( IgG 2 b ) to increase its binding affinity for tumors. The Ce 6 was activated by N -hydroxysuccinimide and directly conjugated with IgG 2 b ( IgG 2 b – Ce 6) via peptide bonds. An average of 11 Ce 6 molecules were coupled to eac